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. 2020 Mar 6;27(8):2500–2516. doi: 10.1038/s41418-020-0518-z

Fig. 3. Fenretinide interferes with complex II of the mitochondrial respiratory chain.

Fig. 3

Flow cytometry analysis of fenretinide (3/4 μM) treated Rh4 and Rh30 cells (upper and lower panel, respectively) in combination with two different inhibitors of complex II of the respiratory chain. Assessed was mitochondrial ROS by staining with MitoSox (10 μM). a Mean fluorescence index of flow cytometry data measured in Rh4 and Rh30 cells treated with fenretinide in combination with 1500 μM of complex II inhibitor carboxin and b 500 μM or 1000 μM TTFA.