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. 2020 Mar 3;27(8):2517–2530. doi: 10.1038/s41418-020-0519-y

Fig. 8. Model of ISG15 induction involved in acquirement of tumor-associated phenotypes by inhibition of autophagy elongation.

Fig. 8

Molecular model for cytosolic dsDNA response-induced STAT1-ISG15 expression in Atg5- or Atg7-depleted cells. The upregulated ISG15 induces acquisition of tumor-associated phenotypes such as migration, invasion, and proliferation.