Fig. 7. Schematic diagram for the role of the m⁶A writer KIAA1429 in oocytes.

KIAA1429 mediates the m⁶A modification on pre-mRNA, then YTHDC1 recognizes the m⁶A signal and recruits SRSF3 to the binding regions on the KIAA1429-mediated pre-mRNA, resulting in exon inclusion together with the spliceosome. With the deletion of Kiaa1429, SRSF3, and YTHDC1 fail to bind pre-mRNA without KIAA1429-mediated m⁶A modification and instead, other factors such as SRSF10 bind to promote exon skipping. These skipped exons lead to the accumulation of aberrant transcripts in oocytes. Consequently, GVBD fails and oocyte growth arrests.