Table 3.

Mediation Analysis: Total Effect of Maternal Polygenic Score (PGS) and Proportion of Total Effect Due to Mediator (Controlling for Child PGS and the Alternative Prenatal Composite)

Outcome and mediator	Total effect (maternal PGS on outcome)	95% CI	Proportion mediated	95% CI	n
Early Years Foundation Stage Profile
SES principal component	0.113	[0.057, 0.164]	.273	[.138, .548]	1,611
Health principal component	0.115	[0.058, 0.169]	.112	[.039, .252]	1,611
Key Stage 1
SES principal component	0.087	[0.025, 0.146]	.321	[.134, .980]	1,267
Health principal component	0.087	[0.024, 0.150]	.131	[.038, .484]	1,267

Note: Total effects are given as standardized coefficients. The rightmost column shows individual ns. CI = confidence interval; SES = socioeconomic status.