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The nuclear factor-κB receptor activator (NF-κB) RANK/RANKL/OPG pathway. The production of nuclear factor-κB receptor activator (NF-κB) ligand (RANKL) leads to a greater differentiation of macrophages into osteoclasts. Bone resorption is stimulated by active osteoclasts, RANKL, and parathyroid hormone (PTH), while it is inhibited by osteoprotegerin (OPG).
