Table 3.
Adherence-related variables.
| Measure of adherence | Time frame | n | % | Mean | SD |
|---|---|---|---|---|---|
| Pharmacy records | |||||
| Proportion refills received/expected refills | Past 12 days | 56 | 0.95 | 0.12 | |
| Proportion non-adherent (i.e. <80% received vs expected refills) |
4 | 7 | - | - | |
| Parent-reported | |||||
| Proportion missed dosesa | Past 28 days | 58 | 0.1 | 0.3 | |
| Proportion non-adherent (i.e. <80% received vs expected refills) |
8 | 14 | - | - | |
| Parental involvement in DMT use | Past 2 weeks | ||||
| Remind | |||||
| 0% | 18 | 27 | |||
| 25% | 13 | 20 | |||
| 50% | 7 | 11 | |||
| 75% | 11 | 17 | |||
| 100% | 14 | 21 | |||
| Missing | 3 | 5 | |||
| Present | |||||
| 0% | 9 | 14 | |||
| 25% | 8 | 12 | |||
| 50% | 7 | 11 | |||
| 75% | 15 | 23 | |||
| 100% | 24 | 36 | |||
| Missing | 3 | 5 | |||
| Administer | |||||
| 0% | 31 | 47 | |||
| 25% | 8 | 12 | |||
| 50% | 4 | 6 | |||
| 75% | 7 | 11 | |||
| 100% | 13 | 20 | |||
| Missing | 3 | 5 | |||
| Reported adherence | No time frame | 60 | 6.3 | 1.4 | |
| Proportion low adherence | 18 | 28 | - | - | |
| Contextual factors | |||||
| Behavioral coping strategiesa | Past 4 weeks | 41 | 51.5 | 11.3 | |
| Side effectsa | Past 4 weeks | 43 | 51.3 | 9.9 | |
| Barriersa | No time frame | 57 | 51.3 | 11.0 | |
| Patient-reported | |||||
| Reported adherenceb | No time frame | 66 | 5.8 | 1.8 | |
| Proportion low adherenceb | 27 | 41 | - | - | |
| Contextual factors | |||||
| Barriersa | No time frame | 58 | 49.6 | 9.2 | |
| Factor scores (standardized) | |||||
| Adherence summary | 49 | 0.0 | 1.0 | ||
| Parent involvement in adherence | 57 | 0.0 | 1.0 |
SD: standard deviation; DMT: disease-modifying therapy.
a
Multiple Sclerosis Treatment Adherence Questionnaire.
b
Morisky Adherence Measure.