Skip to main content
. Author manuscript; available in PMC: 2020 Jul 20.
Published in final edited form as: Subcell Biochem. 2020;94:345–382. doi: 10.1007/978-3-030-41769-7_14

Fig. 14.15.

Fig. 14.15

a Binding of INN-298 (purple and cyan) in a symmetry-related fashion at the α-cleft Hb. Unlike most aromatic aldehydes, four molecules of INN-298 bind per one Hb molecule. The molecules in purple make Schiff-base interactions with αVal1 nitrogen (primary), while the molecules in cyan (secondary) bind non-covalently and significantly weaker. b Detailed interactions of two of the INN-298 molecules (purple and cyan) with Hb. The meta-positioned methoxy-pyridine group of the primary bound INN-298 disposes further down the central water-cavity