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. Author manuscript; available in PMC: 2020 Jul 20.
Published in final edited form as: Subcell Biochem. 2020;94:345–382. doi: 10.1007/978-3-030-41769-7_14

Fig. 14.19.

Fig. 14.19

Crystal structure of TD-3 in complex with T and R structures, where TD-3 forms disulfide bond with βCys93 sulfur atom. Hb α and β subunits are shown as grey and tan, respectively. a The binding of TD-3 with βCys93 in deoxygenated Hb leads to disruption of the T state stabilizing salt-bridge interaction between βAsp94 and βHis146. b The binding of TD-3 in CO-liganded Hb (R structure) prevents possible interaction between βAsp94 and βHis146 that is required to shift the allosteric transition to the T state