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. 2020 May 22;13(2):209–215. doi: 10.3892/mco.2020.2050

Figure 1.

Figure 1

Induction of dermatitis or raw wound areas in a mouse model. (A) Dermatitis on nude mouse dorsal skin was induced by the intraperitoneal (i.p.) injection of 5-FU (60 mg/kg, i.p.) on days 1 and 3, along with mechanical trauma on days 2 and 3 of the experiment. There were three experimental groups as follows: The 5-FU + abrasion group received saline only (1 ml/body/day; n=4); the Elental® TA group received Elental® by TA (18 kcal/100 g body weight/day; n=4); and the Elental® OA group received Elental® by OA (18 kcal/100 g body weight/day; n=4); all administrations were performed daily, starting from day 3 of the experiment until the mice were sacrificed. (B) Raw wound areas on nude mouse dorsal skin were induced by i.p. injection of 5-FU (60 mg/kg, i.p.) on days 1 and 3 of the experiment, followed by dermabrasion with a surgical knife on day 2 of the experiment. There were three experimental groups as follows: The 5-FU + dermabrasion group received saline only (1 ml/body/day; n=4); the Elental® TA group received Elental® by TA (18 kcal/100 g body weight/day; n=4), and the Elental® OA group received Elental® by OA (18 kcal/100 g body weight/day; n=4); all administrations were performed daily, starting from day 3 of the experiment until the mice were sacrificed. 5-FU, 5-fluorouracil; OA, oral administration; TA, topical application.