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. 2020 May 22;13(2):209–215. doi: 10.3892/mco.2020.2050

Figure 5.

Figure 5

Proliferative activity of Elental®-treated HOKs. Elental® exerted a growth-promoting effect on all cells following 24 h of treatment, under both nutritionally poor conditions (medium with 0% OKGS-NZ growth supplement) and nutrient-rich or substantial conditions (medium with 1% OKGS-NZ). Elental® (5-100 µg/ml) exerted a proliferative effect on 5-FU (2 µg/ml)-pretreated HOKs, even under nutritionally poor conditions, after 24 h of treatment. Error bars represent the standard deviation of the mean of three independent experiments. #P<0.05 compared to the control (one-way analysis of variance and Tukey-Kramer multiple comparisons tests). OD, optical density; HOKs, human oral keratinocytes; 5-FU, 5-fluorouracil; OKGS-NZ, Oral Keratinocyte Medium (OKM)-NZ complete medium consisting of OKM basal medium supplemented with 1% oral keratinocyte growth supplement-New Zealand Origin BPE.