Fig. 2.

Function of the Prefoldin Complex. a Prefoldin complex acts as a chaperone protein in the cytoplasm. Prefoldin specifically binds to the cytoplasmic chaperone protein of the loop complex containing TCP-1 (CCT) and acts as a transport molecule to direct the target protein. Once the unfolded protein transported by the prefoldin complex contacts the CCT, Prefoldin will be released automatically and leave the active site. b Schematic model of prefoldin complex against pathogenic forms of Alzheimer’s disease. Human prefoldin (hPFD) can inhibit Aβ fibril formation and contribute to the non-toxic aggregation of Aβ. c The prefoldin complex prevents the pathogenesis of Parkinson’s disease. The prefoldin complex inhibits the early stages of α-synuclein aggregation and assists in autophagy-dependent degradation of α-synuclein-causing mutants by delivering them to lysosomes. d Schematic model of prefoldin complex against pathogenic forms of Huntingtin. Prefoldin complexes can help Huntington proteins to form non-toxic oligomers (dimers to tetramers), and the lack of prefoldin complexes can produce toxic oligomer and inclusion body