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Schematic of PAQosome (PFDL-R2TP). In addition to canonical prefoldin complexes, eukaryotes also have prefoldin-like complexes (PFDL). Among them, the classic α subunits were replaced with (URI and UXT) and some classic β subunits were replaced with PDRG1 and ASDURF. PFDL interacts with other chaperone proteins, such as R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) to form PFDL-R2TP (PAQosome). PAQosome also has additional components Monad and RPB5. Corresponding homologs exist in yeast
