Table 1.

Proteins that physically interact with canonical or prefoldin-like subunits, and research advances in different organisms and diseases

Prefoldin subunits	Function	Organism	Interactor	Disease
β
PFDN1	Oncogene	Human	Cyclin A [36] RABV [39]	Gastric cancer [35] Lung cancer [36] Colon cancer [37] Nasopharyngeal carcinoma [38]
		Mouse		Lymphocyte development [27] Cytoskeletal defect [27]
PFDN2	Oncogene	Human	γ-Synuclein [42]	Gastric cancer [35] Breast cancer [40] Metastatic urothelial carcinoma [41]
		Plant [65]
PFDN4	Oncogene	Human		Atherosclerosis [19] Gastric cancer [35, 52] Breast cancer [48, 49] Colon cancer [51] Hepatocellular carcinoma [50] Atopic dermatitis [53]
PFDN6		Human		Gastric cancer [35] Acute lymphocytic leukemia [64]
		Arabidopsis thaliana [76]	DELLA [67]
		Caenorhabditis elegans	FOXO [77]
α
PFDN3/VBP1	Anti-oncogene	Human	VHL [43] pVHL [44] hMSH4 [45] HDAC1 [46]	Gastric cancer [35]
		Arabidopsis thaliana	DELLA [67]
		Caenorhabditis elegans [66]
PFDN5/MM1	Anti-oncogene	Human	c-Myc [99] TIF1β [101] Rabring7 [127] Egr-1 [128] ARFP/F [129] p73α [133] p63α [134] ΔNp63α [135]	Gastric cancer [35] Secondary hyperparathyroidism [54, 55] Colon cancer [60]
		Mouse		Breast cancer [70– 73]
		Arabidopsis thaliana	DELLA [67]
α-like
URI/Bud27		Human		Cervical cancer [89] Colon cancer [90] Gastric cancer [91]
		Mouse	c-Myc [88]	Hepatocellular carcinoma [85]
		Yeast	Rpb5 [83] TOR [93] PFDN6 [94]
UXT/Art-27			NF-κB [95] Als2 [97]	Androgen receptor [96] Centrosome component [98]
γ
γ-prefoldin				Nanobiotechnology [32–34]