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. 2020 Jul 20;12:64. doi: 10.1186/s13073-020-00759-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Asthma GWAS genes are over-represented among DEGs in response to IL-13 and/or IL-17A and among DEGs in cases compared to controls. In all panels, blue refers to IL-13 treated cells, red to IL-17A treated cells, and purple to IL-13+IL-17A treated cells. a DEGs following exposure to IL-13 and/or IL-17A were enriched for GWAS catalog genes near variants associated with asthma (N = 586) compared to all non-DEGs on the array. The numbers of DEGs for each exposure are shown on the X-axis, and the proportions of GWAS genes are shown on the Y-axis. b The 8 most significant DEGs are listed. The Venn diagram illustrates the total numbers and overlaps of DEGs that are also near SNPs highlighted in asthma GWASs