Figure 1.

Microtubule‐mediated mitochondrial trafficking. A, Kinesin motor complexes containing TRAK and MIRO1 are responsible for moving mitochondria towards the + end of microtubules. Calcium negatively regulates movement by inducing a conformational change on MIRO1, which in turn disengages mitochondria from the microtubules. SNPH is an outer membrane mitochondrial protein that anchors mitochondria via direct binding to microtubules and Kinesin. Dynein motor complexes containing bicaudal 2 (BiCD2) adaptor and MIRO1 move mitochondria towards the − end of microtubules. B, Additional kinesin‐containing complexes have been described in neurons, containing SYBU, FEZ1, or RanBP2