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SNPH prevents metastasis. In tumors with high expression of SNPH, mitochondria are anchored perinuclearly, leading to lower cell invasion and preventing metastatic dissemination in mice. In tumors with loss of SNPH expression, mitochondria are free to move to the cortical cytoskeleton via Kinesin/MIRO1 complexes. These cortical mitochondria fuel enhanced tumor cell invasion and correlate with poorer prognosis in patients
