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. 2020 Jun 19;1(1):e19371. doi: 10.2196/19371

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©Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Rupinder Kaur, Ruchi Kiran Badyal, Ajay Kumar Saxena, Ho-Joon Shin, Michael Kolbe, Kailash C Pandey. Originally published in JMIR Bioinformatics Biotechnol (http://bioinform.jmir.org), 19.06.2020.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Bioinformatics Biotechnol, is properly cited. The complete bibliographic information, a link to the original publication on http://bioinform.jmir.org, as well as this copyright and license information must be included.

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Molecular docking studies of the CTL and HTL MEVs with TLR3. (A), (D): The docking complexes of CTL-TLR3 and HTL-TLR3 with patches on the TLR3 receptor indicating the region of binding sites calculated by PDBsum [60]. (C), (F): Detailed molecular interactions between the binding site residues of the CTL and HTL MEVs and TRL3 (CTL, HTL: cyan; TLR3: magenta). Hydrogen bond formation is shown by orange dotted lines. (B), (E): B-factors of the docked MEVs to the TLR3 receptor. The presentation is in VIBGYOR color, with blue showing a low B-factor and red showing a high B-factor. Most of the MEV regions are blue, showing low B-factors; this indicates the formation of stable complexes with the TLR3 receptor. CTL, cytotoxic T lymphocyte. HTL, helper T lymphocyte. TLR3, toll-like receptor 3.