Table 3:
Response to SMART RCT outcome variables over time in African-American and white PWE
| Baseline Mean (SD) | 10 weeks Mean (SD) | 24 weeks Mean (SD) | Statistic* | Post-hoc | |
|---|---|---|---|---|---|
| Total NHEsa,b past 6 months | |||||
| Non-Hispanic White (n= 26) | 13.69 (19.57) | --- | 8.31 (13.56) | F(1,84)= 2.38, p= 0.13 | ns |
| African-American (n= 64) | 14.67 (35.35) | 5.45 (8.70) | |||
| QOLIE-10c | |||||
| Non-Hispanic White (n= 27) | 3.12 (0.93) | 2.65 (0.88) | 2.86 (0.99) | F(2,162)= 2.63, p= 0.08 | ns |
| African-American (n= 60) | 2.99 (0.95) | 2.85 (0.97) | 2.74 (0.98) | ||
| PHQ-9d | |||||
| Non-Hispanic White (n= 27) | 10.56 (6.84) | 8.15 (6.47) | 8.11 (6.90) | F(2,162)= 1.39, p= 0.25 | ns |
| African-American (n= 63) | 10.75 (7.35) | 10.60 (7.38) | 9.67 (7.01) | ||
| MADRSe | |||||
| Non-Hispanic White (n= 28) | 16.29 (10.66) | 13.71 (11.11) | 14.29 (12.09) | F(2,170)= 2.58, p= 0.08 | ns |
| African-American (n= 63) | 17.97 (11.66) | 17.89 (12.10) | 15.11 (11.95) | ||
| SF-36- MCSf | |||||
| Non-Hispanic White (n= 28) | 40.56 (14.33) | 44.00 (13.86) | 44.23 (13.27) | F(2,168)= 0.85, p= 0.43 | ns |
| African-American (n= 62) | 40.23 (12.77) | 39.66 (13.12) | 42.12 (13.78) | ||
| SF-36- PCSg | |||||
| Non-Hispanic White (n= 28) | 32.40 (10.52) | 44.84 (10.14) | 43.86 (11.64) | F(2,168)= 1.66, p= 0.19 | ns |
| African-American (n= 62) | 41.65 (10.50) | 43.27 (11.12) | 43.53 (11.64) | ||
| LSSSh | |||||
| Non-Hispanic White (n= 27) | 36.02 (31.72) | 26.39 (29.03) | 28.15 (33.38) | F(2,164)= 2.67, p= 0.07 | ns |
| African-American (n= 61) | 29.43 (31.62) | 28.11 (31.19) | 21.89 (30.59) | ||
Repeated measures ANOVAs. The QOLIE-10 and MADRS were adjusted with Huynh-Feldt for a sphericity violation. The statistic column denotes change from baseline accounting for racial group (African American or Non-Hispanic White) and level of education (four years of college or more, 1–3 years of college, or high school or less).
NHE: Negative Health Event, calculated by adding seizure count, hospitalizations, self-harm attempts, accidents, and ER visits
QOLIE-10: Quality of Life in Epilepsy, scores range from 1–5 with higher scores indicating worse quality of life
PHQ-9: Patient Health Questionnaire, scores range from 0 to 27 with higher scores indicating more severe depression
MADRS: Montgomery-Asberg Depression Rating Scale, scores range from 0 to 60 with higher scores indicating more severe depression
SF-36: Short-Form 36;
MCS: Mental Component Score, scores range from 0 to 100, with 100 being the highest or best possible level of mental functioning;
PCS: Physical Component Score, scores range from 0 to 100, with 100 being the highest or best possible level of physical functioning
LSSS: Liverpool Seizure Severity Scale, scores range from 0 to 100 with higher scores indicating more severe seizures