Table 2.
Analysis of Bleeding Risk Factors.
| Parameter | Bleeding (n = 25) | No bleeding (n = 274) | χ2 | P |
|---|---|---|---|---|
| Sexa | ||||
| Male | 16 (64.0) | 123 (44.9) | 3.363 | .067 |
| Female | 9 (36.0) | 151 (55.1) | ||
| Agea | ||||
| 60∼69 | 5 (20.0) | 129 (47.1) | 13.053 | .001 |
| 70∼79 | 9 (36.0) | 100 (36.5) | ||
| ≥80 | 11 (44.0) | 45 (16.4) | ||
| Varicose veinsa | ||||
| Yes | 2 (8.0) | 26 (9.5) | 0.060 | .807 |
| No | 23 (92.0) | 248 (90.5) | ||
| Smokinga | ||||
| Yes | 9 (36.0) | 98 (35.8) | 0.001 | .981 |
| No | 16 (64.0) | 176 (64.2) | ||
| Alcohol consumptiona | ||||
| Yes | 3 (12.0) | 51 (18.6) | 0.677 | .411 |
| No | 22 (88.0) | 223 (81.4) | ||
| Hypertensiona | ||||
| Yes | 11 (44.0) | 119 (43.4) | 0.003 | .956 |
| No | 14 (56.0) | 155 (56.6) | ||
| Diabetes mellitusa | ||||
| Yes | 4 (16.0) | 38 (13.9) | 0.086 | .769 |
| No | 21 (84.0) | 236 (86.1) | ||
| New thrombosisa | ||||
| Yes | 0 (0.0) | 2 (0.7) | - | .840 |
| No | 25 (100.0) | 272 (99.3) | ||
| A daily dose of rivaroxabana | ||||
| 10 mg every day | 3 (3.1) | 94 (96.9) | 12.241 | <.001 |
| 15 mg every day | 4 (5.4) | 70 (94.6) | ||
| 10 mg twice a day | 8 (10.3) | 70 (89.7) | ||
| First 15 mg twice a day after 21 days was changed to 20 mg | 10 (20.0) | 40 (80.0) | ||
| INRb | 1.0 (0.97-1.07) | 0.998 (0.94-1.04) | −1.669 | .095 |
| APTT (seconds)b | 30.15 (28.12-31.82) | 30.10 (27.25-32.80) | −0.103 | .918 |
| PT (seconds)b | 11.70 (11.37-12.50) | 11.50 (11.00-12.20) | −1.865 | .062 |
| PTRb | 1.00 (0.97-1.07) | 0.98 (0.94-1.040) | −1.693 | .091 |
| Fibrinogenb | 3.645 (3.235-4.160) | 3.350 (2.930-3.928) | −1.635 | .102 |
| ALT (U/L)b | 18.60 (14.70-23.25) | 16.95 (11.10-24.60) | −1.056 | .291 |
| AST (U/L)b | 23.850 (20.675-30.20) | 21.80 (18.50-27.05) | −1.524 | .128 |
| Cr (µmol/L)b | 44.5 (6.36-81.60) | 44.9 (5.58-67.37) | −1.141 | .254 |
| BUN (µmol/L)b | 9.62 (6.24-74.05) | 8.87 (5.54-66.55) | −0.972 | .331 |
| D-D (µg/L)b | 2205.0 (397.0-4030.0) | 1070 (433.75-3272,50) | −0.747 | .455 |
| PLT (109/L)b | 190.0 (149.0-255.0) | 203.0 (169.0-245.0) | −0.765 | .444 |
| PTA (%)c | 93.17 ± 11.94 | 98.78 ± 12.23 | 2.008 | .046 |
Abbreviations: ALT, alanine aminotransferase; APTT, activated part thromboplastin time; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine; D-D; D-Dimer; INR, international standardized ratio; PLT, platelet count; PT, prothrombin time; PTA, prothrombin activity; PTR, prothrombin time ratio; fibrinogen, SD, standard deviation.
a Expressed as frequency and percentage (%).
b Expressed as median (interquartile range).
c Expressed as mean ± SD.