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. Author manuscript; available in PMC: 2020 Dec 9.
Published in final edited form as: Biomacromolecules. 2019 Nov 15;20(12):4380–4388. doi: 10.1021/acs.biomac.9b01057

Figure 2. The presence of actin in composites hinders transport and leads to more pronounced anomalous subdiffusion across a wide spatiotemporal range.

Figure 2.

(A) Mean-squared displacements (MSD) divided by lag time Δt, as determined from particle-tracking. Slopes report scaling exponents of α - 1, such that a particle undergoing normal diffusion exhibits a slope of 0 whereas subdiffusion results in negative slopes. As shown, all composites exhibit φA-dependent subdiffusion (increasingly negative slopes), with the actin network causing the most pronounced subdiffusion with α = 0.6. (B) The decay time, τ, of density fluctuations with wave vector q are determined from DDM. Plots of 1/(q2τ) vs. q would yield a slope of 0 for normal diffusion. The upward slopes we observe indicate subdiffusion for all composites with the actin network exhibiting the greatest degree of subdiffusion (α = 0.57).