Figure 7.

Phospho-PDGF-Rβ/GFAP co-localization in the cortical region below the EMS. (a) Photomicrographs of the cortical region below the EMS on day 42 showing an increased GFAP-positive signal in animals receiving VEGF, PDGF or VIP myoblasts together with marked phospho-PDGF-Rβ expression. Bar = 100 µm. (b) High-power magnification showing astrocytic GFAP/phospho-PDGF-Rβ co-localization. Bar = 50 µm. (c) Quantification of the percent phospho-PDGF-Rβ-coverage of the GFAP-positive surface area; *p<0.05.

EV: empty vector; VEGF: vascular endothelial growth factor; PDGF: platelet-derived growth factor; GFAP: glial fibrillary acidic protein.