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. 2019 Jan 7;40(2):392–403. doi: 10.1177/0271678X18822474

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Figure 3. — Mature ADAM10 protein levels were significantly reduced in eNOS^+/− microvascular tissue. (a) Microvascular tissue from 18-month-old eNOS^+/− and wild type animals was Western blotted using anti-APP, anti-BACE1, anti-ADAM10, and anti-Actin (loading control) antibodies. Representative image is shown. Densitometric analysis was performed for (b) APP (n = 6 animals), (c) BACE1 (n = 7 animals), and (d) ADAM10 (n = 5 animals; *P < 0.05). BACE enzymatic activity was measured from 18-month-old eNOS^+/− and wild type (e) microvascular tissue via a commercially available BACE activity assay kit (n = 3–4). All data are presented as mean ±SD with individual data points shown.