PS1, a major γ-secretase component, was significantly increased in microvascular
tissue of eNOS+/− mice. (a) Microvascular tissue from 18-month-old
eNOS+/− and wild type animals was analyzed by Western blot analyses for
γ-secretase components: PS1, PS2, nicastrin, Pen2, and Aph1. Representative image is
shown. Densitometric analysis was performed for (b) PS1 (n = 6
animals; *P < 0.05), (c) PS2 (n = 4 animals),
(d) nicastrin (n = 6 animals), (e) Pen2 (n = 6
animals), and (f) Aph1 (n = 4 animals). All data are presented as
mean±SD with individual data points shown.