Table 2.
COVID-19 cohort (n = 309) | Pre-COVID-19 cohort (n = 407) | p value | |
---|---|---|---|
Mean age in years (± SD) | 70 (14) | 69 (16) | 0.18 |
Male, n (%) | 183/309 (59) | 190/407 (47) | < 0.001 |
Mean systolic blood pressure (mmHg ± SD)a | 154 (28) | 155 (28) | 0.31 |
Mean diastolic blood pressure (mmHg ± SD)b | 90 (18) | 87 (19) | 0.09 |
Median NIHSS (IQR)c | 4 (2–9) | 4 (2–7) | 0.55 |
Median O2 saturation (IQR)d | 98 (96–99) | 97 (96–99) | 0.57 |
Fever on admission (> 38 degrees Celsius, n (%)) | 5/226 (2) | 12/289 (4) | 0.22 |
Medical history | |||
Stroke or TIA, n (%) | 101/309 (33) | 132/407 (32) | 0.94 |
Atrial fibrillation, n (%) | 55/309 (18) | 56/407 (14) | 0.15 |
Diabetes mellitus, n (%) | 58/309 (18) | 66/407 (16) | 0.43 |
Hypertension, n (%) | 153/309 (50) | 178/407 (44) | 0.12 |
Hypercholesterolemia | 81/309 (26) | 76/407 (19) | 0.02 |
Coronary artery disease | 53/309 (17) | 54/407 (13) | 0.15 |
Smoking, n (%) | 92/309 (29) | 123/407 (30) | 0.90 |
Medication use | |||
Statin, n (%) | 113/309 (37) | 155/407 (38) | 0.67 |
Anticoagulation, n (%) | 31/309 (10) | 52/407 (13) | 0.26 |
Antiplatelet, n (%) | 95/309 (31) | 117/407 (28) | 0.56 |
Anti-hypertensive, n (%) | 162/309 (52) | 210/407 (52) | 0.98 |
Laboratory on admission | |||
Mean thrombocyte count × 103 per mm3 (± SD)e | 237 (68) | 243 (79) | 0.28 |
Mean leucocyte count × 103 per mm3 (± SD)f | 9.3 (6.6) | 9.1 (9.2) | 0.77 |
Mean C-reactive protein in mg/L (± SD)g | 13.4 (41.4) | 10.7 (30.8) | 0.24 |
Mean glucose in mmol/L (± SD)h | 7.9 (3.4) | 7.6 (3.8) | 0.35 |
Onset of symptoms | 0.07 | ||
Witnessed, n (%) | 170/309 (56) | 242/407 (60) | |
Wake-up, n (%) | 62/309 (20) | 55/407 (14) | |
Unknown, n (%) | 73/309 (24) | 104/407 (27) | |
In-hospital occurrence of ischemic stroke, n (%) | 10/309 (6) | 6/407 (3) | 0.36 |
Process measures | |||
Onset-to-door time (median, minutes, IQR)i | 187 (71–606) | 150 (75–544) | 0.39 |
Door-to-CT brain (median, minutes, IQR)j | 13 (8–22) | 12 (8–21) | 0.42 |
Large vessel occlusion, n (%) | 46/180 (26) | 42/194 (22) | 0.44 |
Missing values, n (%): a36 (5), b36(5), cIschemic stroke patients only, no missing values. d83 (12), e71 (10),f44 (6), g71 (10), h83 (12), IFor patients with unwitnessed onset of symptoms, the last-seen-well time was used to calculate the time interval between onset of symptoms and arrival at first hospital, 131 (18), j 64 (9)