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. Author manuscript; available in PMC: 2021 Sep 28.
Published in final edited form as: Cancer Lett. 2020 May 30;488:40–49. doi: 10.1016/j.canlet.2020.05.027

Fig. 2.

Fig. 2.

MTM weakens the transcription activity of AR in PCa. A, Density plots of ChIP-seq reads for AR occupied regions in VCaP cells with MTM treatment. The x-axis shows 2 kb 5′ and 3′ to the predicted peak summits. The y-axis depicts read depth in ChIP-seq. B, Heat map of ChIP-seq signals around AR peak in VCaP cells with MTM treatment. C, A list of the lost gene motifs in AR bound regions under MTM treatment. D, Fold change of ChIP-qPCR of PSA enhancer in LNCaP/GFP, LNCaP/AR-V7 and LNCaP/ARv567es cells with MTM treatment. E, Fold change of ChIP-qPCR of FKBP5 enhancer in LNCaP/GFP, LNCaP/AR-V7 and LNCaP/ARv567es cells with MTM treatment. F, Venn diagram representing AR binding lost peaks (≥2 Folds change) and downregulated genes upon MTM treatment in VCaP cells. G, GSEA of double strand break repair in VCaP cells with MTM treatment.