A, Culture model of prostate cancer explants. B, Representative images of Ki-67 staining in PCa explants with MTM treatment. C, Quantification of Ki67 positive cells in PCa explants with MTM treatment. D, Western blot of γ-H2AX, p-Chk2 and AR in MTM and IR co-treated PCa explants. E, Average number of γ-H2AX Foci in MTM and IR co-treated PCa explants. F, Representative images of γ-H2AX Foci in MTM and IR co-treated PCa explants.