TABLE 1.
Overview of identified gastrointestinal malignancy‐associated circRNAs
| Type of cancer | CircRNA | Expression | Host gene | Chromosome | Putative function | Potential clinical value | Type of biomarker | Target | Sample detected | References |
|---|---|---|---|---|---|---|---|---|---|---|
| Gastric cancer | hsa_circ_0000096 | Down | HIAT1 | Chr1 | miRNA sponge | Biomarker | Diagnosis | Not investigated | Tissues | [79] |
| hsa_circ_0000190 | Down | CNIH4 | Chr1 | miRNA sponge | Biomarker | Diagnosis | Not investigated | Tissues and plasma | [17] | |
| hsa_circ_0005654 | Down | PRDM5 | Chr4 | miRNA sponge | Biomarker | Diagnosis | Not investigated | Tissues | [80] | |
| hsa_circ_0032627 (circDLST) | Up | DLST | Chr14 | miRNA sponge | Biomarker | Prognosis | miR‐502‐5p | Tissues | [81] | |
| hsa_circ_0004339 (circ‐DONSON) | Up | DONSON | Chr21 | via NURF complex | Biomarker | Prognosis | Not investigated | Tissues | [51] | |
| hsa_circ_0002320 (circYAP1) | Down | YAP1 | Chr11 | miRNA sponge | Biomarker | Prognosis | miR‐367‐5p/p27 Kip1 axis | Tissues | [82] | |
| hsa_circ_0000199 (circAKT3) | Up | AKT3 | Chr1 | miRNA sponge | Therapeutic target | Prognosis | miR‐198 | Tissues | [49] | |
| hsa_circ_0081143 | Up | COL1A2 | Chr7 | miRNA sponge | Biomarker | Prognosis | miR‐646 | Tissues | [83] | |
| hsa_circ_0000993 | Up | ATL2 | Chr2 | miRNA sponge | Biomarker | Prognosis | miR‐214‐5p | Tissues | [84] | |
| hsa_circ_0000140 | Down | KIAA0907 | Chr1 | Not investigated | Biomarker | Diagnosis | Not investigated | Tissues and plasma | [85] | |
| circLARP4 | Up | LARP4 | Chr12 | miRNA sponge | Biomarker | Prognosis | miR‐424‐5p | Tissues | [86] | |
| hsa_circ_0130810 (circ‐KIAA1244) | Down | KIAA1244 | Chr6 | Not investigated | Biomarker | Diagnosis and prognosis | Not investigated | Tissues, plasma and cells | [53] | |
| hsa_circ_0000745 | Down | SPECC1 | Chr17 | Not investigated | Biomarker | Diagnosis | Not investigated | Tissues, plasma and cells | [87] | |
| circ‐PSMC3 | Down | PSMC3 | Chr11 | miRNA sponge | Biomarker | Diagnosis and prognosis | miR‐296‐5p | Tissues and cells | [52] | |
| Hepatocellular cancer | hsa_circ_0016788 | Up | TRIM11 | Chr1 | Not investigated | Biomarker | Diagnosis | miR‐486/CDK4 pathway | Tissues and cells | [88] |
| hsa_circ_0007874 (circMTO1) | Down | MTO1 | Chr6 | miRNA sponge | Biomarker and therapeutic target | Diagnosis | miR‐9 | Tissues and cells | [56] | |
| hsa_circ_0001445 (cSMARCA5) | Down | SMARCA5 | Chr4 | miRNA sponge | Biomarker and therapeutic target | Prognosis | miR‐17‐3p and miR‐181b‐5p | Tissues | [58] | |
| hsa_circ_0010090 (circFBLIM1) | Up | FBLIM1 | Chr1 | miRNA sponge | Biomarker | Diagnosis | miR‐346 | Tissues and cells | [57] | |
| circZKSCAN1 | Down | ZKSCAN1 | Chr7 | ceRNA | Biomarker | Diagnosis | Not investigated | Tissues | [89] | |
| hsa_circ_0000567 (circSETD3) | Down | SETD3 | Chr14 | miRNA sponge | Biomarker | Prognosis | miR‐421 | Tissues and cells | [29] | |
| hsa_circRNA86 62‐12 (circTRIM33‐12) | Down | TRIM33‐12 | Chr1 | miRNA sponge | Biomarker | Prognosis | miR‐191 | Tissues and cells | [90] | |
| hsa_circ_0005075 | Up | EIF4G3 | Chr1 | miRNA sponge | Therapeutic target | Diagnosis | miR‐431 | Tissues and cells | [91] | |
| hsa_circ_0072088 (circZFR) | Down | ZFR | Chr5 | miRNA sponge | Biomarker | Not investigated | miR‐511 | Tissues and cells | [92] | |
| circSMARCA5 | Down | SMARCA5 | Chr4 | Not investigated | Biomarker | Diagnosis | Not investigated | Tissues, plasma and cells | [93] | |
| hsa_circ_0000284 (circHIPK3) | Up | HIPK3 | Chr11 | miRNA sponge | Not investigated | Not investigated | Not investigated | Not investigated | [94] | |
| Colorectal cancer | hsa_circ_0009361 | Down | GNB1 | Chr1 | miRNA sponge | Biomarker | Diagnosis | miR‐582 | Tissues and cells | [95] |
| hsa_circ_0136666 | Up | PRKDC | Chr8 | miRNA sponge | Biomarker and therapeutic target | Prognosis | miR‐136 | Tissues and cells | [96] | |
| hsa_circ_0006990 (circVAPA) | Up | VAPA | Chr18 | miRNA sponge | Biomarker and therapeutic target | Diagnosis | miR‐101 | Tissues and plasma | [60] | |
| hsa_circ_0055625 (circ_0055625) | Up | DUSP2 | Chr2 | miRNA sponge | Biomarker | Diagnosis | miR‐106b‐5p | Tissues | [97] | |
| hsa_circ_0000284 (circHIPK3) | Up | HIPK3 | Chr11 | miRNA sponge | Biomarker and therapeutic target | Prognosis | miR‐7 | Tissues and cells | [62] | |
| hsa_circ_0142527 | Down | PREX2 | Chr8 | miRNA sponge | Biomarker | Diagnosis | Not investigated | Tissues | [98] | |
| Pancreatic cancer | hsa_circ_0005397 (circRHOT1) | Up | RHOT1 | Chr17 | miRNA sponge | Therapeutic target | Not investigated | miR‐26b, miR‐125a, miR‐330, and miR‐382 | Tissues and cells | [99] |