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. Author manuscript; available in PMC: 2021 Mar 4.
Published in final edited form as: Curr Opin Struct Biol. 2020 Mar 4;60:167–174. doi: 10.1016/j.sbi.2020.01.015

Fig. 3. Monobodies that modulate biological functions of their respective targets and their crystal structures.

Fig. 3.

(a) Allosteric activator and inhibitor of Aurora A kinase. (b) Competitive inhibitors of the interaction between SH2 domains and pY peptides. (c) Competitive inhibitor of the interaction between WDR5 and a fragment of MLL1. (d) Allosteric inhibitor targeting the interface between the Bcr-Abl SH2 and kinase domains. (e) Allosteric inhibitor targeting the self-association surface of HRAS.