Table 1 |.
Ongoing RCTs in OCD
| Title | Design | Interventions | Population | NCT number |
|---|---|---|---|---|
| Psychotherapy | ||||
| An eHealth intervention for OCD in youths with autism spectrum disorder | Open-label | Internet CBT | Children and adolescents | NCT03473080 |
| Treatment effects of family based CBT in children and adolescents with OCD | RCT | Family-based CBT versus family-based psychoeducation/relaxation training | Children and adolescents | NCT03595098 |
| Internet-delivered CBT for paediatricOCD | RCT | Internet-delivered CBT versus CBT | Children and adolescents | NCT03263546 |
| Overlapping neural circuits in paediatric OCD | Open-label | ERP and when indicated medication treatment | Children and adolescents | NCT02421315 |
| Clinical outcomes in paediatric OCD | RCT | Croup-based family CBT versus waitlist | Children and adolescents | NCT01635569 |
| Neurocircuit mechanisms of OCD across the lifespan | RCT | CBT, stress management therapy, optional CBT for adolescents and adults; fMRI only for healthy control adolescents and adults | Adolescents and adults | NCT02437773 |
| Quality assessment in exposure therapy | Open-label | Exposure therapy | Children, adolescents and adults | NCT03182101 |
| BIP in Jamtland Harjedalen: increased access to CBT within regular healthcare in northern Sweden | Open-label | Internet CBT | Children and adolescents | NCT02926365 |
| Building an outcomes assessment infrastructure to assess anxiety treatment | Open-label | CBT | Children and adolescents | NCT02305537 |
| Metacognitive therapy for OCD | RCT | Metacognitive therapy versus ERP | Adults | NCT02867449 |
| Internet-based versus face-to-face CBT for OCD | RCT | CBT (face-to-face) versus internet-based CBT versus internet-based CBT without therapist support | Adults | NCT02541968 |
| Fear extinction and mechanisms of change in OCD | RCT | Exposure therapy versus waitlist | Adults | NCT02467374 |
| Cognitive training in OCD | Open-label | n-Back (cognitive training) | Adults | NCT02818088 |
| Inference-based cognitive therapy versus ERPforOCD | RCT | Inference-based cognitive therapy versus ERP | Adults | NCT03677947 |
| Decision-making impairments in OCD: an integrated behavioural economics model | Open-label | Decision-making tasks | Adults | NCT03420495 |
| Mindfulness meditation utilizing an EEG biofeedback device for the treatment for OCD | RCT | Mindfulness meditation versus waitlist | Adults | NCT03273699 |
| Feasibility, acceptability, and preliminary efficacy of a mobile app (nOCD) for OCD | Open-label | Therapist-assisted mobile intervention | Adults | NCT03476902 |
| Cognitive checking intervention for maladaptive beliefs about memory | RCT | CBT for maladaptive beliefs about memory versus treatment as usual | Adults | NCT03241056 |
| Mindfulness-based cognitive therapy: efficacy and fMRI-based response predictors in a group of OCD patients | RCT | Mindfulness-based intervention versus treatment as usual | Adults | NCT03128749 |
| Computerized training for individuals diagnosed with obsessive-compulsive and related disorders | Open-label | Computerized training | Adults | NCT03182075 |
| The role of cognitive control in the transdiagnostic conceptualization of “Intrusive thoughts” | Open-label | Cognitive control tasks and script driven imagery | Adults | NCT03414619 |
| Pharmacotherapy | ||||
| Efficacy of adding topiramate to current treatment in refractory OCD | RCT | Topiramate versus placebo | Adults | NCT00182520 |
| Fear conditioned response in healthy subjects and in OCD patients pretreatment and post-treatment with sertraline | Open-label | Sertraline | Adults | NCT03068429 |
| Pharmaco(epi)genetic study of OCD | Open-label | SSRIs and clomipramine | Adults | NCT02431845 |
| A pilot study examining the gut microbiota in patients with OCD versus healthy controls and following 12 weeks of open-label SSRI treatment | Open-label | SSRIs | Adults | NCT02285699 |
| BHV-4157 in adult subjects with OCD | RCT | BHV-4157 versus placebo | Adults | NCT03299166 |
| A study of pregabalin (Lyrica) augmentation in serotonin reuptake inhibitor-refractory OCD | RCT | Pregabalin versus placebo | Adults | NCT00994786 |
| TolcaponeinOCD | Randomized and crossover trial | Tolcapone versus placebo | Adults | NCT03348930 |
| Efficacy of psilocybin in OCD: a double-blind, placebo-controlled study | RCT | Psilocybin versus niacin | Adults | NCT03356483 |
| Understanding how ketamine brings about rapid improvement in OCD | RCT | Ketamine versus midazolam | Adults | NCT02624596 |
| Probiotic treatment in adult OCD | RCT | Probiotic formula (LactobaciUus helveticus R0052 and Bifidobacterium longum R0175) versus placebo | Adults | NCT02334644 |
| Effects of marijuana on symptoms of OCD | RCT | High-THC/low-CBD marijuana versus low-THC/high-CBD marijuana versus placebo | Adults | NCT03274440 |
| Effect of vitamin C on SSRI-treated OCD patients | RCT | SSRI plus vitamin C versus SSRI | Adults | NCT03754647 |
| Effects of ondansetron in obsessive-compulsive and tic disorders | RCT | Ondansetron versus placebo | Adults | NCT03239210 |
| Psilocybin for treatment of OCD | RCT | High-dose psilocybin versus low-dose psilocybin versus lorazepam | Adults | NCT03300947 |
| Bioequivalence study of paroxetine tablets and Paxil under fasting and fed conditions in Chinese healthy volunteers | RCT | Paroxetine hydrochloride tablet 20 mg versus Paxil 20 mg | Adults | NCT03504475 |
| Psychotherapy and pharmacotherapy | ||||
| Efficacy of ERP and SSRIs in Chinese OCD patients | Randomized and crossover trial | Fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and ERP | Adolescents and adults | NCT02022709 |
| Influence of pregnenolone on exposure therapy in OCD | RCT | Exposure therapy with pharmacological facilitation versus exposure therapy | Adults | NCT01949753 |
| The study of mindfulness-based cognitive therapy and OCD | RCT | Mindfulness-based cognitive therapy versus psychoeducation versus SSRI | Adults | NCT03179839 |
| Cannabinoid medication for adults with OCD | RCT | Nabilone versus nabilone plus ERP | Adults | NCT02911324 |
| Open/aftercare treatment for participants diagnosed with OCD | Open-label | Pharmacotherapy versus psychotherapy | Adults | NCT03511534 |
| The study of the pathogenesis and cognitive behavioural group therapy in OCD | RCT | CBT versus SSRI versus CBT plus SSRI | Adults | NCT02739061 |
| Psychotherapy and transcranial magnetic stimulation | ||||
| Neuromodulation enhanced cognitive restructuring: a proof-of-concept study | RCT | Cognitive restructuring plus rTMS (left) versus cognitive restructuring plus rTMS (right) versus cognitive restructuring plus sham rTMS | Adults | NCT02573246 |
| Neuromodulation | ||||
| tDCS for treatment-resistant OCD | RCT | Active tDCS versus sham | Adults | NCT03304600 |
| tDCS as an add-on treatment in SSRI-resistant OCD | RCT | Active tDCS versus sham | Adults | NCT02407288 |
| Neurocircuitryof OCD: modulation by tDCS | Open-label | tDCS | Adults | NCT02704117 |
| TMS in OCD: mechanisms and biomarkers | RCT | Active TMS versus sham | Adults | NCT02355002 |
| rTMS over the supplementary motor area for treatment-resistant OCD | RCT | Active rTMS versus sham | Adults | NCT03211221 |
| rTMS in OCD | RCT | Active rTMS versus placebo rTMS | Adults | NCT02884674 |
| Tolerability, safety and efficacy of the H AC-coil deep TMS in medication-resistant OCD subjects | Randomized and crossover trial | Low-frequency TMS versus high-frequency TMS versus sham | Adults | NCT01343732 |
| rTMS in treatment-refractory OCD | Randomized and crossover trial | Active rTMS versus sham | Adults | NCT02450695 |
| Study of magnetic brain stimulation in treatment of OCD | RCT | Active TMS versus sham | Adults | NCT02018185 |
| rTMS treatment for OCD | RCT | Active TMS versus sham | Adults | NCT03393078 |
| Theta burst stimulation for compulsive behaviour noninvasive brain stimulation study | RCT | Continuous theta burst stimulation (cTBS) pattern TMS and habit override practice versus intermittent theta burst stimulation (iTBS) pattern TMS and habit override practice | Adults | NCT03265015 |
| Magnetic seizure therapy for treatment-resistant depression, schizophrenia and OCD | Open-label | Magnetic seizure therapy | Adults | NCT01596608 |
| NeurofeedbackforOCD | RCT | Neurofeedback versus control feedback | Adults | NCT02206945 |
| Neurosurgery | ||||
| Reclaim DBS therapy for OCD | Open-label | Reclaim DBS therapy | Adults | NCT02773082 |
| DBS for OCD: improving targeting precision | RCT | Microelectrode-assisted technique versus standard technique | Adults | NCT02377375 |
| DBS of the bilateral habenula for treatment-refractory OCD | Open-label | Bilateral surgical implantation of DBS system to habenula | Adults | NCT03463590 |
| Novel DBS in ventral capsule and stratum for refractory OCD | Randomized and crossover trial | Active stimulation: stimulator on followed by off versus sham stimulation: stimulator off followed by on | Adults | NCT02590445 |
| Combined cortical/subcortical recording and stimulation as a circuit-oriented treatment for OCD | Open-label | Medtronic primary celland sensing DBS | Adults | NCT03184454 |
| Development of adaptive DBS for OCD | Case series | DBS discontinuation follow-up | Adults | NCT03457675 |
| DBS and OCD | RCT | DBS of subthalamic nucleus versus DBS of ventral striatum | Adults | NCT01329133 |
| European study of quality of life in resistant OCD patients treated by STN DBS | RCT | DBS versus psychotherapy and pharmacological treatment | Adults | NCT02844049 |
| Efficacy and adverse events of bilateral single-shot ventral capsular or ventral striatal gamma capsulotomy for OCD: a pilot study | Open-label | Gamma ventral capsulotomy | Adults | NCT02433886 |
| Evaluation of capsulotomy by linear accelerator radiosurgery in severe and refractory OCD | Open-label | Bilateral gamma-knife capsulotomy | Adults | NCT02500888 |
| Trial of MR-guided focused ultrasonography (MRgFUS) bilateral capsulotomy for the treatment of refractory OCD | Open-label | Focused ultrasonography | Adults | NCTO3156335 |
CBD, cannabidiol; CBT, cognitive behavioural therapy ; DBS, deep brain stimulation; EEG, electroencephalography ; ERP, exposure and response prevention; fMRI, functional MRI; MR, magnetic resonance; OCD, obsessive–compulsive disorder ; RCT, randomized controlled trial; rTMS, repetitive transcranial magnetic stimulation; SSRI, selective serotonin reuptake inhibitor ; STN, subthalamic nucleus; tDCS, transcranial direct current stimulation; THC, tetrahydrocannabinol; TMS, transcranial magnetic stimulation.