Fig. 1.
Schematic presentation of X-linked hACE2 and other critical genes in COVID-19. Females host two alleles, whereas males only one. SNPs, rearrangements, epigenetic changes (red spot: abnormal allele, green spot: normal) on Xp22.2 and other Xp bands affect directly normal structure, expression and function of the corresponding proteins in males. (hACE2: human Angiotensin-Converting Enzyme 2, TLR7/8: Toll –like Receptors 7 and 8, FOXP3: Forkhead Box P3, RGN: ReGucalciN; SNP: single nucleotide polymorphisms; Ca2+: calcium)