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. 2020 Jun;30(6):803–813. doi: 10.1101/gr.255620.119

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© 2020 Boot et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Mutational signature of duocarmycin SA (duoSA). (A) duoSA, one of the naturally occurring duocarmycins. (B) Several views of the conformation of duoSA intercalated with DNA (source: PDB ID: 1DSM) (Smith et al. 2000; Rose et al. 2018). Duocarmycins slot into the minor groove of the DNA helix. (C) SBS mutation spectrum of one of the duoSA-treated HepG2 clones. (D) Transcriptional strand bias of T > A mutations induced by duoSA as a function of gene expression. (E) Extended sequence context specificity of T > A mutations induced by duoSA. (F) Indel spectrum of one of the duoSA-treated HepG2 clones.