Table 2.
Overall distribution of LAG3, CD8 and TP53 mutations depending on clinical/tumor criteria; percentages per variable are displayed in parentheses
| LAG3 | CD8+ inflammation | TP53 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | p | Not inflamed | Inflamed | p | Not mutated | Mutated | p | |
| Age group | |||||||||
| < 65 years | 52 (71.2) | 15 (51.7) | 52 (66.7) | 17 (63) | 49 (71) | 16 (51.6) | |||
| ≥ 65 years | 21 (28.8) | 14 (48.3) | 26 (33.3) | 10 (37) | 20 (29) | 15 (48.4) | |||
| Gender | |||||||||
| m | 35 (47.3) | 12 (41.4) | 35 (44.3) | 13 (48.1) | 30 (42.9) | 16 (51.6) | |||
| w | 39 (52.7) | 17 (58.6) | 44 (55.7) | 14 (51.9) | 40 (57.1) | 15 (48.4) | |||
| Alcohol | |||||||||
| No | 49 (80.3) | 20 (83.3) | 55 (83.3) | 16 (76.2) | 49 (84.5) | 18 (72) | |||
| Yes | 10 (16.4) | 4 (16.7) | 10 (15.2) | 4 (19) | 9 (15.5) | 5 (20) | |||
| Abuse | 2 (3.3) | 0 (0) | 1 (1.5) | 1 (4.8) | 0 | 2 (8) | |||
| Nicotine | |||||||||
| No | 50 (80.6) | 18 (78.3) | 55 (83.3) | 15 (71.4) | 48 (82.8) | 18 (72) | |||
| Yes | 12 (19.4) | 5 (21.7) | 11 (16.7) | 6 (28.6) | 10 (17.2) | 7 (28) | |||
| Therapy | |||||||||
| Surgery | 31 (46.3) | 8 (30.8) | 34 (47.2) | 7 (30.4) | 33 (52.4) | 6 (21.4) | |||
| +RTX/CTX | 36 (53.7) | 18 (69.2) | 38 (52.8) | 16 (69.6) | 30 (47.6) | 22 (78.6) | |||
| T | |||||||||
| T1 | 21 (30) | 2 (7.1) | 19 (25.7) | 5 (18.5) | 23 (33.8) | 0 | 0.02 | ||
| T2 | 14 (20) | 11 (39.3) | 19 (25.7) | 6 (22.2) | 15 (22.1) | 8 (28.6) | |||
| T3 | 15 (21.4) | 4 (14.3) | 16 (21.6) | 5 (18.5) | 13 (19.1) | 7 (25) | |||
| T4a | 14 (20) | 8 (28.6) | 12 (16.2) | 10 (37) | 12 (17.6) | 9 (32.1) | |||
| T4b | 6 (8.6) | 3 (10.7) | 8 (10.8) | 1 (3.7) | 5 (7.4) | 4 (14.3) | |||
| N | |||||||||
| N0 | 47 (69.1) | 11 (39.3) | 0.001 | 50 (67.6) | 11 (44) | 0.008 | 48 (71.6) | 10 (35.7) | <0.001 |
| N1 | 8 (11.8) | 1 (3.6) | 8 (10.8) | 1 (4) | 7 (10.4) | 2 (7.1) | |||
| N2a | 0 | 2 (7.1) | 0 | 2 (8) | 2 (3) | 0 | |||
| N3 | 13 (19.1) | 14 (50) | 16 (21.6) | 11 (44) | 10 (14.9) | 16 (57.1) | |||
| UICC stadium | |||||||||
| I | 17 (25.4) | 2 (7.4) | 0.009 | 16 (22.2) | 4 (16) | 19 (28.4) | 0 | <0.001 | |
| II | 13 (19.4) | 7 (25.9) | 15 (20.8) | 5 (20) | 14 (20.9) | 5 (19.2) | |||
| III | 14 (20.9) | 1 (3.7) | 16 (22.2) | 1 (4) | 13 (19.4) | 3 (11.5) | |||
| IVa | 7 (10.4) | 2 (7.4) | 6 (8.3) | 3 (12) | 8 (11.9) | 1 (3.8) | |||
| IVb | 15 (22.4) | 12 (44.4) | 18 (25) | 9 (36) | 10 (14.9) | 16 (61.5) | |||
| IVc | 1 (1.5) | 3 (11.1) | 1 (1.4) | 3 (12) | 3 (4.5) | 1 (3.8) | |||
RTX: radiotherapy, CTX: chemotherapy