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Amodiaquine de-ethylation and midazolam 1′-hydroxylation in HLM vs. HLM-MGBS. The HLM concentration used was 0.25 mg/ml. (A) Hyperbolic curve for CYP2C8-mediated amodiaquine de-ethylation. (B) Hyperbolic curves for CYP3A4-mediated midazolam hydroxylation. Values represent the means ± S.D. from N = 3 replicates for each substrate concentration evaluated.
