. 2020 Aug;48(8):645–654. doi: 10.1124/dmd.120.090696

TABLE 1.

Kinetic parameters (mean ± S.D.) describing metabolism of amodiaquine and midazolam in HLM suspensions and HLM-MGBS

Parameter	Amodiaquine (CYP2C8)		Midazolam (CYP3A)
Parameter	HLM^SI	HLM-MGBS^SI	HLM^MM	HLM-MGBS^SI
K_m (µM)	0.732 ± 0.11	1.21 ± 0.08^ns	0.612 ± 0.086	2.04 ± 0.23^sig
V_max (pmol/min per milligram)	982 ± 89	1030 ± 87^ns	2002 ± 66	4350 ± 249^sig
CL_int (µl/min per milligram)	1341	851	2828	2132

MM, Michaelis-Menten modeling used; ns, not significantly different from parameter generated using HLM; SI, substrate inhibition modeling used; sig, significantly different from parameter generated using HLM (P < 0.05).