Table 2.
Partial list of V. cholerae C6706 genes identified by RNA-seq analysis whose expression changed following ZAC-3 IgG treatment.
| Gene | Annotation | Δ log2a |
|---|---|---|
| VCA1028 | Maltoporin (OmpS) | 5.20 |
| VC0911 | Trehalose-6-phosphate hydrolase | 4.22 |
| VCA0247 | Transcriptional repressor UlaR | 4.01 |
| VC1649 | Serine protease (vesC) | 3.83 |
| VC0910 | PTS system trehalose(maltose) transporter subunits IIBC | 3.65 |
| VCA0860 | Alpha-amylase (MalS) | 3.44 |
| VCA0945 | Maltose ABC transporter substrate-binding protein (MalE) | 3.43 |
| VCA0908 | Hypothetical protein | 3.4 |
| VCA0944 | Maltose transporter membrane protein (MalF) | 3.26 |
| VC0606 | Nitrogen regulatory protein P-II | 3.23 |
| VCA0136 | Glycerophosphodiester phosphodiesterase (GlpQ) | −3.54 |
| VCA0137 | sn-glycerol-3-phosphate transporter (GlpT) | −3.56 |
| VC0089 | Cytochrome c551 peroxidase | −3.58 |
| VC1778 | Hypothetical protein | −3.65 |
| VC0795 | Citrate/sodium symporter | −3.70 |
| VC0797 | Citrate lyase subunit gamma | −3.77 |
| VC0796 | Citrate (pro-3S)-lyase ligase | −3.79 |
| VCA0684 | Regulatory protein UhpC | −4.15 |
| VCA0685 | Hexose ABC transporter substrate-binding protein | −4.94 |
| VCA0687 | Hexose ATP-binding subunit | −5.11 |
| VC0713 | Hypothetical protein | −5.26 |
| VCA0686 | Hexose ABC transporter permease | −5.36 |
a
Genes with highest fold change in response to ZAC-3 IgG treatment, as compared to cells treated with an isotype control. Genes were whose expression changed > 2-fold log2 and with a q value < 0.01 were designated as significant.