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. 2020 Jul 20;15(7):e0235638. doi: 10.1371/journal.pone.0235638

Table 2. Opacification of the paranasal sinuses before and after one year of ivacaftor therapy.

Paranasal sinus component Pre ivacaftor∞ Post ivacaftor# p—value× p—valueα KCC
Best caseΔ (25th-75th IQR) Worst case∑ (25th-75th IQR) Best caseΔ (25th-75th IQR) Worst case∑ (25th-75th IQR) Pre Post
Maxillary sinus right 2.00 (1.00–2.00) 2.00 (2.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.015 0.014 0.429 0.175
Maxillary sinus left 2.00 (1.00–2.00) 2.00 (2.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–1.00) 0.015 0.015 0.175 0.286
Anterior ethmoid right 1.00 (1.00–2.00) 2.00 (1.00–2.00) 0.00 (0.00–0.00) 1.00 (0.00–1.00) 0.015 0.023 0.061 0.228
Anterior ethmoid left 1.00 (1.00–2.00) 2.00 (2.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–1.00) 0.014 0.014 0.306 0.197
Posterior ethmoid right 0.00 (0.00–0.00) 1.00 (1.00–1.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.317 0.020 0.505 0.095
Posterior ethmoid left 0.00 (0.00–1.00) 1.00 (1.00–1.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.157 0.034 0.294 0.095
Sphenoid right 0.00 (0.00–1.25) 0.50 (0.00–1.25) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.180 0.102 0.167 0.167
Sphenoid left 0.00 (0.00–1.25) 0.00 (0.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.180 0.157 0.167 0.333
Frontal sinus right 2.00 (1.00–2.00) 2.00(1.75–2.00) 0.00(0.00–0.00) 0.00 (0.00–0.00) 0.038 0.034 0.167 0.167
Frontal sinus left 2.00 (1.00–2.00) 2.00 (1.50–2.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.059 0.046 0.333 0.000
OMC right 0.00 (0.00–2.00) 2.00 (2.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.083 0.014 0.114 0.286
OMC left 2.00 (0.00–2.00) 2.00 (2.00–2.00) 0.00 (0.00–0.00) 0.00 (0.00–0.00) 0.025 0.014 0.143 0.286

Abbreviations: ∞: Median Lund-Mackay score of sinus opacification before introduction of ivacaftor scored by four otolaryngologists. #: Median Lund-Mackay score of sinus opacification after one year ivacaftor scored by four otolaryngologists. ×: p-value of comparison between best case before and best case after one year ivacaftor. α: p-value of comparison between worst case before and worst case after one year ivacaftor. KCC: Kendall’s coefficient of concordance pre and post ivacaftor use. Δ: Median of best cases scored by four observers with modified Lund-Mackay score. ∑: Median of worst cases scored by four observers with the modified Lund-Mackay score. 25th,75th IQR: 25th percentile and 75th percentile inter quartile range of L-M scores. OMC: ostiomeatal complex, significant: p≤0,05