Table 4. Frequency of sinonasal symptoms and endoscopic signs before and after the introduction of ivacaftor therapy.

Aspect of sinonasal disease	Pre ivacaftor	Post ivacaftor
Rhinorrhea
No symptoms, No. (%)	4 (50)	5 (63)
Occasionally symptoms, No. (%)	1 (13)	0 (0)
Often symptoms, No. (%)	3 (38)	0 (0)
Continuous symptoms, No. (%)	0 (0)	2 (25)
Nasal obstruction
No symptoms, No. (%)	3 (38)	8 (100)
Occasionally symptoms, No. (%)	4 (50)	0 (0)
Often symptoms, No. (%)	1 (13)	0 (0)
Continuous symptoms, No. (%)	0 (0)	0 (0)
Postnasal drip
No symptoms, No. (%)	6 (75)	8 (100)
Occasionally symptoms, No. (%)	1 (13)	0 (0)
Often symptoms, No. (%)	1 (13)	0 (0)
Continuous symptoms, No. (%)	0 (0)	0 (0)
Facial pain
No symptoms, No. (%)	6 (75)	8 (100)
Occasionally symptoms, No. (%)	0 (0)	0 (0)
Often symptoms, No. (%)	1 (13)	0 (0)
Continuous symptoms, No. (%)	0 (0)	0 (0)
Headache
No symptoms, No. (%)	2 (25)	5 (63)
Occasionally symptoms, No. (%)	4 (50)	2 (25)
Often symptoms, No. (%)	2 (25)	0 (0)
Continuous symptoms, No. (%)	0 (0)	0 (0)
Anosmia
No symptoms, No. (%)	4 (50)	5 (63)
Occasionally symptoms, No. (%)	1 (13)	0 (0)
Often symptoms, No. (%)	1 (13)	0 (0)
Continuous symptoms, No. (%)	0 (0)	0 (0)
Nasal polyps
No polyps, No. (%)	4 (50)	7 (88)
In middle meatus only, No. (%)	4 (50)	1 (13)
Beyond middle meatus, No. (%)	0 (0)	0 (0)
Discharge
No discharge, No. (%)	4 (50)	7 (88)
Clear thin discharge, No. (%)	4 (50)	0 (0)
Thick purulent discharge, No.(%)	0 (0)	0 (0)
Edema
Absent, No. (%)	7 (88)	4 (50)
Mild, No. (%)	1 (13)	3 (38)
Severe, No. (%)	0 (0)	0 (0)

Abbreviations: No.: number of patients