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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Immunol. 2020 Apr 13;204(11):2984–2994. doi: 10.4049/jimmunol.1901091

Figure 4. VAD mice exhibited T cell exhaustion and died in the persistent viral infection.

Figure 4.

VAC and VAD mice were infected with LCMV Cl13 (2×106 FFU). A) Survival rates. B) Expression of PD-1 on CD8+ T cells. C) Multifunctional CTLs in the spleens. D) Viremia and lung viral loads at 48 dpi. The data are shown as mean ± SEM of four mice per group from a single representative experiment in B-D panels. The experiment was repeated twice independently. A two-tailed Student’s t-test was used to compare the two groups. * P<0.05, ** P<0.01, *** P<0.001.