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Graphs showing inversely proportional relationship between infusate MW and Vd in multiple settings. A: In the 3- to 20-kDa range, this relationship was linear (R2 = 0.99 in all settings). B: For acute CED and osmotic pump over a broader range, 570 Da up to 150 kDa, this relationship was better modeled by exponential decay regression (R2 = 0.91 for acute CED and 0.96 for acute osmotic pump).
