. 2020 Jul 16;11:77–90. doi: 10.2147/POR.S251120

Table 2.

Data Collection in the CHRONICLE Study

HCP-reported data

Patient-reported outcomes

Enrollment

Patient characteristics
- Eligibility criteria and demography
- Asthma history

Enrollment + every 6 months:

Patient characteristics
- Social,^a environmental,^a and smoking history/status
- Respiratory and nonrespiratory comorbidities
- Major medical events and procedures^a
Treatment characteristics
- Current asthma treatment and select other treatments
- If asthma treatment changed, reason for change
Health outcomes^b
- Vital signs^a and physical exam^a
- Asthma exacerbations and hospitalizations
- Nonasthma hospitalizations^a
- Most recent imaging, FeNO, spirometry, PFTs
- BAL/sputum testing (all)
- CBC with differential (all)^a
- Most recent other lab tests^a
- Diagnosed malignancies, serious infections, anaphylaxis
- Clinical trial participation^a
- Assessment of overall patient and treatment status

Enrollment only

Health literacy^a

Enrollment + monthly

Medication adherence^a
Asthma exacerbations^a
ACT^a

Enrollment + every 3 months

Asthma-related HCRU^a
Work productivity (WPAI-Asthma)^a
Assessment of treatment effectiveness^a

Enrollment + every 6 months

Quality of life: SGRQ^a
Source of prescription medications^a
Presence of asthma treatment plan^a

Notes: ^aVariables not assessed in ISAR. ^bBone densitometry data obtained using dual-energy x-ray absorptiometry (DEXA) are collected in ISAR but not the CHRONICLE study.

Abbreviations: ACT, Asthma Control Test; BAL, bronchoalveolar lavage; CBC, complete blood count; FeNO, fractional exhaled nitric oxide; HCP, health care provider; HCRU, health care resource utilization; ISAR, International Severe Asthma Registry; PFT, pulmonary function test; SGRQ, St. George’s Respiratory Questionnaire; WPAI-Asthma, Work Productivity and Activity Impairment Asthma questionnaire.