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. 2020 Jul 16;12:5845–5855. doi: 10.2147/CMAR.S248698

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© 2020 Guo et al.

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MCM3AP-AS1/miR-15a/EIF4E axis pathway regulates the sensitivity of doxorubicin to lymphoma both in vitro and in vivo. (A and B) Daudi and Namalwa cells were co-transfected with siNC/siMCM3AP-AS1 and miR-15a NC/miR-15a inhibitor for 24 hours, then doxorubicin was added and Western blotting was performed. *P<0.05, **P<0.01, ***P<0.0001. (C and D) Lymphoma cells were treated as (A), then the cell viability and apoptosis rates were measured by CCK-8 and flow cytometry. *P<0.05. (E) Daudi and lymphoma cells were pre-transfected with MCM3AP-AS1 siRNA or siNC, then cells were injected subcutaneous to build the xenograft tumor model. ***P<0.0001. (F) The expression levels of PARP, EIF4E and Mcl-1 were detected by Western blotting in the xenograft tumor tissues. **P<0.01, ***P<0.0001.