Table 6.
Stem Cell Collection Data: 6 Induction Cycles
Parameter | VRD Arm | KRD Arm |
---|---|---|
Precollection BM cellularity, %, mean ± SD (P = .148) | 35.8 ± 13.1 | 39.2 ± 15.1 |
Time from end of induction therapy to start of collection, d, median (range) (P = .479) | 29 (10-100) | 24 (9-195) |
G-CSF and plerixafor-based stem cell mobilization, n (%) | 39 (92.9) | 89 (98.9) |
Chemotherapy-based stem cell mobilization, n (%) | 3 (7.1) | 1 (1.1) |
Premobilization hematologic parameters, mean ± SD | ||
WBCs (P =.03) | 6 ± 2.7 | 4.9 ± 2.2 |
Hemoglobin (P = .0001) | 12.5 ± 1.3 | 11.4 ± 1.1 |
Platelets (P = .498) | 198.3 ± 63.9 | 209.8 ± 89.3 |
WBC count at start of collection, mean ± SD (P = .354) | 48.9 ± 16.5 | 46 ± 18.9 |
Days to complete stem cell collection, mean (P = .024) | 1.81 | 2.21 |
1 day, % | 40 | 30 |
2 days, % | 40 | 32.2 |
3 days, % | 16.7 | 27.8 |
4 days, % | 2.4 | 10 |
Collection failures (<2 × 106 CD34+ cells/kg), n (%) (P = .9) | 1 (2.4) | 6 (6.7) |
Suboptimal collection(<5 × 106 CD34+ cells/kg), n (%) | 2 (4.8) | 16 (17.8) |