Table 6.

Multivariable GEE analyses of the effects of curative-intent lung cancer treatment on outcomes (N = 35). Fatigue (significant exploratory outcome, BFI)

Variable	β (95% CI)	p value
Smoking history	N/A (F-statistics)	< 0.001
HFrEF (N/Y)	− 15.3 (− 30.8, 0.27)	0.054
Anxiety/depression/PTSD (N/Y)	− 36.4 (− 56.8, − 16.0)	0.001
Smoking history × anxiety/depression/PTSD	N/A	0.001
Time effect(post/pre-treatment)	+ 9.97 (+ 2.89, + 17.0)	0.006

Variables in italics indicate time effect (post-/pre-treatment) on outcomes

β, regression coefficient; BFI, Brief Fatigue Inventory; CI, confidence interval; EORTC-QLQ-C30, European Organization for Research and Treatment of Cancer QoL Questionnaire Core 30; GEE, generalized estimating equations; PTSD, post-traumatic stress disorder