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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2020 May 28;64:112–123. doi: 10.1016/j.ceb.2020.04.003

Figure 1. The FET proteins are nuclear import cargos of Kapβ2.

Figure 1.

A. Domain organization. B. PY-NLS sequences with Kapβ2-binding epitopes underlined. C. Structure of Kapβ2 (cyan) bound to FUS PY-NLS (magenta; 4FDD). Left, cartoon representation of Kapβ2. Right, surface representation with a schematic of FUS domains. RRM (2LCW) and ZnF (6G99) domains. D. Protomers of short FUS LC segments (crystal structures of 37SYSGYS42 (yellow), 54SYSSYGQS61 (pink) and 77STGGYG81 (grey)) and solid-state NMR structure of FUS LC (residues 1–214; green). All four segments form cross-β structures.