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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2020 May 28;64:112–123. doi: 10.1016/j.ceb.2020.04.003

Figure 3. TDP-43 is a nuclear import cargo of the Impα/β heterodimer. A, B.

Figure 3.

Domain organization (A) and the bipartite cNLS sequence (B) of TDP-43 (Impα-binding epitopes underlined). C. Structures of Impα (cyan) bound to the bipartite cNLS of Nucleoplasmin (magenta) (1EJY) and of Impβ (blue) bound to the IBB of Impα (cyan) (1QGK), along with the schematic of TDP-43 domains: 1) NTD (5MDI) connected to the the Nucleoplasmin cNLS (a model for the TDP-43 cNLS), followed by RRM1-RRM2 (4BS2) and a schematic of the LC domain. D. Left to right: Cryo-EM structures of TDP-43 segment spanning residues 311–360 (three polymorphic cross-β structures), residues 286–331 which self-associates into one cross-β structure, and the solution NMR structure of monomeric TDP-43 residues 311–360.