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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2020 May 15;26(8):1552–1556. doi: 10.1016/j.bbmt.2020.04.010

Figure 1: 15-PGDH inhibition attenuates the severity of murine autoimmune bone marrow failure.

Figure 1:

(A) Schematic depicting the disease model, in which CB6F1/J mice are induced via 3Gy irradiation and infusion with 8e6 C57BL/6 lymph node (LN) cells, and subsequently treated with PGDHi or vehicle (Veh) control, beginning at day 4. (B) Complete blood count analysis of white blood cells (WBCs), neutrophils (NE), and platelets (PLT) in radiation alone controls (grey bars), and aplastic anemia mice treated with vehicle- (blue), or PGDHi- (red), 13 days post-induction. N=21 experimental mice/group. (C) Kaplan-Meier survival curve. N=5 Rad ctrl, and 10 Veh- and PGDHi-treated mice/group. (D-E) Quantification of burst-forming unit erythroid (BFU-E) and colony-forming unit granulocyte, monocyte (CFU-GM) per 100K BM cells. N=5-6 mice/group.