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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2020 May 15;26(8):1552–1556. doi: 10.1016/j.bbmt.2020.04.010

Figure 2: PGDHi does not alter inflammatory cytokine levels in peripheral blood serum or BM lymphocyte frequencies.

Figure 2:

(A) Measurement of IFNγ, TNFα, IL-6, and IL-1β in peripheral blood serum of radiation control (grey), and aplastic anemia mice treated with vehicle- (blue), and PGDHi- (red), 14 days post-induction. N=17-18 experimental mice/group. (B) Representative CD90 histograms (top; gated on single bone marrow cells), and CD8 (x) and CD4 (y) plots (bottom; gated on CD90+ bone marrow cells) from radiation control (Rad Ctrl), and Veh-, and PGDHi-treated aplastic anemia mice. (C-D) Quantification of the absolute number (C), and frequency (D), of CD8+ and CD4+ lymphocytes. Frequency represented as percent indicated population among total bone marrow cells (BMCs). N=5-6 mice/group. Two-tailed student’s t-test used to compare Veh-versus PGDHi-treated mice for all parameters.