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. 2020 Jul 14;12:5759–5771. doi: 10.2147/CMAR.S245283

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© 2020 Qiu et al.

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ISOV inhibits migration and invasion and reverses the EMT phenotype in HCSLCs. Effects of ISOV (20, 40, 80 and 160 μM) on cell viability (A) in L-02 cells, MHCC97H cells and HCSLCs (n=3; *P<0.05 vs vehicle (ISOV 0 μM); ^#P<0.05 vs 80 μM ISOV; one-way ANOVA). Effects of ISOV (5, 10, 20 μM) on MnSOD and FoxM1 protein levels (B) and cell migratory and invasive capacities (C and D), E-cadherin, N-cadherin, Twist1 and MMP-2 protein amounts (E and F) in HCSLCs (n=3; *P<0.05 vs vehicle (ISOV 0 μM); ^#P<0.05 vs 5.0 μM ISOV; one-way ANOVA).