Table 1.
Characteristics of Patients with HSV-1 and HSV-2 in Cerebrospinal Fluid, and Their Corresponding Comparison Cohorts, Denmark, 2000–2016
| Characteristics | HSV-1 Cohort | Population Comparison Cohort HSV-1 | HSV-2 Cohort | Population Comparison Cohort HSV-2 |
|---|---|---|---|---|
| Total | 208 | 2080 | 283 | 2830 |
| Female sex – no. (%) | 112 (54) | 1120 (54) | 201 (71) | 2010 (71) |
| Median age at study inclusion – years (interquartile range) | 60 (41–70) | 60 (41–70) | 38 (28–48) | 38 (28–48) |
| Age below 16 years at study inclusion (%) | 16 (8) | 160 (8) | 7 (2) | 70 (2) |
| Age between 20–60 years at study inclusion (%) | 90 (43) | 900 (43) | 247 (87) | 2470 (87) |
| Born in Denmark – no. (%) | 197 (95) | 1922 (92) | 266 (94) | 2486 (88) |
| High school education (%) | 111 (53) | 1116 (54) | 188 (66) | 1893 (67) |
| Charlson Comorbidity Index score >0 – no. (%)¶,$ | 73 (35) | 547 (26) | 57 (20) | 366 (13) |
| Cancer, total – no. (%)$ | 29 (14) | 192 (9) | 21 (7) | 108 (4) |
| Median observation time – years (interquartile range) | 3.7 (0.7–9.1) | 6.2 (2.5–10.1) | 5.2 (2.2–9.9) | 5.5 (2.7–10.5) |
| Total observation time, years | 1071 | 13,431 | 1671 | 18,114 |
| Died – no. (%)# | 69 (33) | 288 (14) | 21 (7) | 77 (3) |
| Diagnosed with cancer – no. (%)# | 12 (6) | 161 (8) | 7 (2) | 83 (3) |
| Diagnosed with dementia – no. (%)# | 7 (3) | 21 (1) | 0 (0) | 7 (0) |
| Emigrated – no. (%)# | 3 (1) | 26 (1) | 11 (4) | 43 (2) |
| Lost to follow up – no. (%)# | 0 (0) | 1 (0) | 0 (0) | 5 (1) |
Notes: ¶The Charlson Comorbidity Index (CCI) score derived from diagnoses recorded in the Danish National Patient Registry at study inclusion. For simplicity, we dichotomized scores (CCI score=0 and CCI score >0). $Diagnosed before study inclusion, #After study inclusion.
Abbreviations: HSV-1, herpes simplex virus type 1; HSV-2, herpes simplex virus type 2.