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. 2020 Jul 16;5(4):1113–1126. doi: 10.1016/j.bioactmat.2020.07.002

Fig. 2.

Fig. 2

DPSC-Exo/CS rescues epithelial lesion and alveolar bone loss in P mice. (A) A flow diagram showing the time of periodontal injection. (B) 3D reconstructions of maxillae of PBS-, CS-, DPSC-Exo- and DPSC-Exo/CS-treated groups (n = 6 per group) were generated by micro-CT. The vertical line extends from the CEJ to the ABC. The CEJ-ABC distance was measured at six predetermined sites on both the buccal and palatal sides. Scale bar = 400 μm. (C) Histological H&E-stained sections of the periodontium from each group are shown. The vertical line extends from the CEJ to the ABC. The CEJ-ABC distance was quantified in each microscope field of view. Scale bar = 200 μm. (D) Histological TRAP-stained sections of the periodontium from each group are shown. Osteoclasts are stained red. The number of osteoclasts was quantified in each microscope field of view. Scale bar = 100 μm. (E) Statistical analysis of the CEJ-ABC distance in each group (n = 6 per group) as determined by micro-CT. Error bar represents SEM. *p < 0.05. (F) Statistical analysis of the CEJ-ABC distance in each group (n = 6 per group) as determined by H&E staining. Error bar represents SEM. *p < 0.05. (G) Statistical analysis of the number of osteoclasts in each group (n = 6 per group) as determined by TRAP staining. Error bar represents SEM. *p < 0.05.